After completing this course, students will be able to define the procedures and methods for risk analysis of chemicals regarding the functioning of the ecosystem and human health. Lectures will introduce the basic methods for the evaluation of human and ecological risk, clarify the difference of exposure parameters and their influence on the final prediction of risks and definition of the main routes of exposure (oral, dermal, inhalation, dietary exposure). Students will be able to characterize and quantify the significance of the potential exposure risks, identify factors the most significant to influence the overall risk and interpret the acceptable risk thresholds. The course will include practical exercise on risk quantification of defined exposure scenario (case studies).